Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1983-4-7
pubmed:abstractText
We have found that the transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus all contain tightly bound lipid. This modification could play a role in the binding of these proteins to cellular membranes. The lipid associated with p60src, the transforming protein of Rous sarcoma virus, is located in the NH2-terminal domain of the polypeptide. This is the region of the protein that has been shown previously to participate in binding the protein to membranes. Two mature forms of p21, the transforming protein of Harvey sarcoma virus, contain lipid. Lipid is not, however, associated with newly synthesized p21. While mature p60src and p21 are bound to cellular membranes, the newly synthesized forms of these proteins are not. The posttranslational addition of lipid may therefore be the means by which these proteins acquire an affinity for membranes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
465-74
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:6297767-Abelson murine leukemia virus, pubmed-meshheading:6297767-Animals, pubmed-meshheading:6297767-Avian Sarcoma Viruses, pubmed-meshheading:6297767-Carcinoma, Squamous Cell, pubmed-meshheading:6297767-Cell Line, pubmed-meshheading:6297767-Cell Transformation, Neoplastic, pubmed-meshheading:6297767-Chickens, pubmed-meshheading:6297767-Humans, pubmed-meshheading:6297767-Leukemia Virus, Murine, pubmed-meshheading:6297767-Oncogene Protein p21(ras), pubmed-meshheading:6297767-Oncogene Protein pp60(v-src), pubmed-meshheading:6297767-Palmitic Acid, pubmed-meshheading:6297767-Palmitic Acids, pubmed-meshheading:6297767-Protein Binding, pubmed-meshheading:6297767-Receptors, Cell Surface, pubmed-meshheading:6297767-Receptors, Transferrin, pubmed-meshheading:6297767-Retroviridae, pubmed-meshheading:6297767-Transferrin, pubmed-meshheading:6297767-Viral Proteins
pubmed:year
1982
pubmed:articleTitle
The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.