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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2 Pt 1
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pubmed:dateCreated |
1983-4-7
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pubmed:databankReference |
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pubmed:abstractText |
The oncogene (v-myb) of avian myeloblastosis virus and a large portion of its cellular homolog (c-myb) have been molecularly cloned and sequenced. The portion of c-myb we analyzed contains seven interspersed segments (or exons). Fusion of these exons creates a continuous nucleotide sequence that is remarkably similar to the sequence of v-myb and that potentially encodes a protein very similar to that specified by v-myb. Comparisons between the sequences of v-myb and c-myb indicate that transduction of c-myb to form v-myb probably resulted from an initial DNA rearrangement and the subsequent use of a spliced RNA as an intermediate.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
453-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6297766-Animals,
pubmed-meshheading:6297766-Avian leukosis virus,
pubmed-meshheading:6297766-Avian myeloblastosis virus,
pubmed-meshheading:6297766-Bacteriophage lambda,
pubmed-meshheading:6297766-Base Sequence,
pubmed-meshheading:6297766-Chickens,
pubmed-meshheading:6297766-Cloning, Molecular,
pubmed-meshheading:6297766-DNA Restriction Enzymes,
pubmed-meshheading:6297766-Genes, Viral,
pubmed-meshheading:6297766-Oncogenes,
pubmed-meshheading:6297766-Transduction, Genetic
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pubmed:year |
1982
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pubmed:articleTitle |
Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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