Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-4-7
pubmed:abstractText
Mouse and human DNA used as in vitro-labeled "high-complexity" probes revealed hybridization between specific herpesvirus DNA fragments on Southern transfers and repetitive sequences present at 10(3) to 10(5) copies per mammalian cell genome. Several different sites of major cell-virus sequence homology have been detected in both the herpes simplex virus type 1 and type 2 genomes, and these are located predominantly within the L and S inverted repeat regions and near the center of the L unique region. The hybrids persisted even in relatively stringent conditions, and appear to correlate closely with some of the previously recognized regions of size heterogeneity in the viral genome. Cloned viral DNA fragments from each site hybridized to different sets of discrete bands and dispersed elements within restriction-endonuclease-digested genomic DNA from a variety of vertebrate species. Localized cell-virus homology was also detected in both the human Epstein-Barr virus and cytomegalovirus genomes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:6297753-Animals, pubmed-meshheading:6297753-Base Sequence, pubmed-meshheading:6297753-Cell Nucleus, pubmed-meshheading:6297753-Cells, Cultured, pubmed-meshheading:6297753-Cloning, Molecular, pubmed-meshheading:6297753-DNA, pubmed-meshheading:6297753-DNA, Recombinant, pubmed-meshheading:6297753-DNA, Viral, pubmed-meshheading:6297753-DNA Restriction Enzymes, pubmed-meshheading:6297753-Genes, Viral, pubmed-meshheading:6297753-Humans, pubmed-meshheading:6297753-Liver, pubmed-meshheading:6297753-Male, pubmed-meshheading:6297753-Mice, pubmed-meshheading:6297753-Mice, Inbred BALB C, pubmed-meshheading:6297753-Nucleic Acid Hybridization, pubmed-meshheading:6297753-Plasmids, pubmed-meshheading:6297753-Repetitive Sequences, Nucleic Acid, pubmed-meshheading:6297753-Sea Urchins, pubmed-meshheading:6297753-Simplexvirus, pubmed-meshheading:6297753-Spermatozoa
pubmed:year
1982
pubmed:articleTitle
Homology between mammalian cell DNA sequences and human herpesvirus genomes detected by a hybridization procedure with high-complexity probe.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't