rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1983-4-15
|
pubmed:abstractText |
Monocyte chemotactic responsiveness (MCR) in 14 patients with small cell anaplastic bronchogenic carcinoma was depressed before treatment compared with the MCR in 28 normal controls (P = 0.00004). MCR was subsequently monitored during combination chemotherapy and after 6 months the MCR had become normalized compared with pretreatment values (P = 0.00006). In addition, chemotactic factor inhibitor (CFI) activity in plasma was measured before treatment and after 6 months. When incubated with plasma before treatment casein had 62% of normal activity and when incubated with plasma after chemotherapy, 81% of normal activity (P = 0.0009). CFI activity decreased by greater amounts in patients in complete remission than in patients in partial remission or in non-responders (P = 0.01). This study supports the concept that cancer patients have depressed monocyte function. Chemotherapy seems to enhance monocyte chemotaxis in vitro and to decrease CFI activity in plasma.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0340-7004
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
13-5
|
pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6297715-Adult,
pubmed-meshheading:6297715-Aged,
pubmed-meshheading:6297715-Antineoplastic Agents,
pubmed-meshheading:6297715-Carcinoma, Small Cell,
pubmed-meshheading:6297715-Chemotactic Factors,
pubmed-meshheading:6297715-Chemotaxis, Leukocyte,
pubmed-meshheading:6297715-Cyclophosphamide,
pubmed-meshheading:6297715-Drug Therapy, Combination,
pubmed-meshheading:6297715-Female,
pubmed-meshheading:6297715-Humans,
pubmed-meshheading:6297715-Lomustine,
pubmed-meshheading:6297715-Lung Neoplasms,
pubmed-meshheading:6297715-Male,
pubmed-meshheading:6297715-Methotrexate,
pubmed-meshheading:6297715-Middle Aged,
pubmed-meshheading:6297715-Monocytes,
pubmed-meshheading:6297715-Vincristine
|
pubmed:year |
1982
|
pubmed:articleTitle |
Normalization of defective monocyte chemotaxis during chemotherapy in patients with small cell anaplastic carcinoma of the lung.
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pubmed:publicationType |
Journal Article
|