Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-3-24
pubmed:abstractText
The murine Ia antigens, encoded by the I region of the major histocompatibility complex, are cell-surface glyco-proteins (consisting of alpha and beta polypeptides) thought to be involved in the control of immune responsiveness. Mice of haplotypes b, s, q, and f fail to express one of the Ia antigen complexes, the E complex, on the cell surface. We have attempted to determine at the molecular level how such a defect (or defects) might be generated. By using I-region E alpha and A alpha gene probes for analyses of RNA and DNA structure, it was possible to conclude that at least three mechanisms can operate. Mice of haplotypes b and s bear a deletion in the E alpha gene, f haplotype mice synthesize predominantly an E alpha mRNA of aberrant size, and mice of the q haplotype seem to have a defect in RNA processing or a problem with mRNA stability, or both.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-1084902, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-330085, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-386836, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-573889, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6101206, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6154735, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6159641, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6280057, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6300851, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6772444, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6792289, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6799608, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-6937437, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-7015151, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-70301, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296871-92520
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't