Linked Life Data

6296850

Source:http://linkedlifedata.com/resource/pubmed/id/6296850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
1983-3-24
pubmed:abstractText
The effect of carlorie intake on the development of spontaneous mammary tumors in virgin C3H mice was studied. Only about 10% of the mice fed a low-calorie diet [10 kcal/day (1 kcal = 4.184 kJ)] since weaning developed mammary tumors, compared to about 60% of those mice that were reared on high-calorie diets (16 kcal/day or lab chow ad lib). In order to understand the mechanism by which a low-calorie diet decreases the occurrence of mammary tumors in mice, we compared the sex cycle, the amounts of circulating thyroid-stimulating hormone (thyrotropin), growth hormone, and prolactin, the production of type A and B virus particles in the mammary glands, and the morphology of the mammary glands of mice fed low- and high-calorie diets. The amount of serum prolactin and the synthesis of type A and B particles in mammary tissues of mice fed a low-calorie diet was markedly decreased compared to those of age-matched mice fed high-calorie diets. In addition, in young mice fed a low-calorie diet, there were fewer mammary alveolar lesions than in mice fed a high-calorie diet, although the size of the lesions was similar. However, in older mice fed the high-calorie diet, the number and size of these lesions were greater than in the mice raised on the low-calorie diet. The other factors that we studied were not affected by calorie restriction. Our findings suggest that the reduction in serum prolactin level, mammary tumor virus production, and proliferation of mammary alveolar lesions associated with dietary calorie restriction is responsible for lowering the incidence of mammary tumors in mice.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-1085916, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-13736091, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-191183, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-3605, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-4303880, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-4823517, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-5023679, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-5690733, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-6260696, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-6285470, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-65833, http://linkedlifedata.com/resource/pubmed/commentcorrection/6296850-89801
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7758-62
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Low-calorie diet prevents the development of mammary tumors in C3H mice and reduces circulating prolactin level, murine mammary tumor virus expression, and proliferation of mammary alveolar cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't