Linked Life Data

6295846

Source:http://linkedlifedata.com/resource/pubmed/id/6295846

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-3-11
pubmed:abstractText
Bovine adrenocortical cells in primary culture actively incorporated [35S]sodium sulphate and [3H]glucosamine into glycosaminoglycans (GAGs). Most of the synthesized GAGs were found associated with the pericellular material and secreted in the culture medium, while less than 15% remained associated with the cell pellet. In all these fractions the major product was identified by its molecular properties and selective degradation procedures as a heparan sulphate structure. Exposure of the cells to ACTH induces a shift of the synthesized GAGs from the cellular to the pericellular compartment, an increase in the heparan sulphate labelling and the occurrence of an additional product characterized as a hyaluronate. These data suggest that GAG metabolism of the adrenocortical cell may be under hormonal control and open the possibility of a modulation of cell activity through modifications of its GAG components, especially those involved in the cell matrix architecture.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0303-7207
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
645-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Control of glycosaminoglycan metabolism by ACTH in bovine adrenocortical cells in primary culture.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't