Linked Life Data

6294157

Source:http://linkedlifedata.com/resource/pubmed/id/6294157

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-2-14
pubmed:abstractText
Numerous experimental studies on the beta-adrenergic receptor suggested that the adenylate cyclase activity is correlated to the number of agonist-receptor complexes. In S49 lymphoma cells, it has been previously shown that, for a given number of occupied receptors, the level of adenylate cyclase activity depends on the total number of receptors. Here we propose and demonstrate that such a behaviour can be accounted for by the cyclic model of Cassel and Selinger provided the diffusion of the receptor in the plane of the membrane is explicitly introduced in the model. The key properties of this expanded version of the model are related to the relative kinetics of receptor diffusion and of agonist dissociation from the receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0095-1544
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Modulation of catecholamine activation of adenylate cyclase by the number of active beta-adrenergic receptors: theoretical considerations on the role of receptor diffusion in the cell membrane.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't