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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1983-2-14
|
| pubmed:abstractText |
1. The activity of the overall Na+-K+-ATPase reaction was inhibited by indomethacin in vitro. 2. The K+-NPPase activity was also inhibited by indomethacin. 3. The activity of Na+-dependent phosphorylation of Na+-K+-ATPase was activated by indomethacin. 4. Indomethacin required for 50% inhibition of K+-NPPase activity was 0.4 mM. 5. Inhibition mode of indomethacin for both the substrate and K+ in K+-NPPase reaction was competitive type. 6. The Ki values for indomethacin for the substrate and K+ in K+-NPPase reaction were 0.4 and 0.24 mM, respectively. 7. Inhibitory effect of indomethacin on K+-NPPase was reversible.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0306-3623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
375-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6293911-4-Nitrophenylphosphatase,
pubmed-meshheading:6293911-Animals,
pubmed-meshheading:6293911-Hydrogen-Ion Concentration,
pubmed-meshheading:6293911-Indomethacin,
pubmed-meshheading:6293911-Kinetics,
pubmed-meshheading:6293911-Phosphorylation,
pubmed-meshheading:6293911-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:6293911-Swine,
pubmed-meshheading:6293911-Time Factors
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Mode of inhibition of activity of Na+-K+-stimulated adenosine triphosphatase by indomethacin.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|