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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1978-4-26
pubmed:abstractText
The overall, static, open-loop gain of the negative-feedback arterial pressure control system was determined repeatedly in anesthetized cats under normal and hypovolumic states. The gain, H, was assessed as (deltaAPI/deltaAPS)-1, where deltaAPI is the immediate fall and deltaAPS the steady-state fall in arterial pressure following a stepwise reduction in blood volume. When the step size was increased from 1.25 to 25% of the total blood volume, H decreased from 30 to less than unity. Considering this amplitude dependence of H, a small amount (1.25%) of quick (in less than 0.3 s) hemorrhage was used to determine H throughout the rest of the experiments. Time-dependent variation of H was evident after a large amount (6.25%) of blood loss. During the initial 10 min, H increased to 126% of the control value, decreased to 43% over the subsequent 20--70 min, and showed a trend toward recovery. The small signal analysis permits a quantitative characterization of the time and input size dependent nature of the arterial pressure control system after various degrees of hemorrhage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
234
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R104-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Overall characteristics of arterial pressure control system studied by mild hemorrhage.
pubmed:publicationType
Journal Article