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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1983-1-7
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pubmed:abstractText |
Ten milligrams nifedipine was administered orally to young and old persons with or without hypertension, and the acute effects of nifedipine on the renin-angiotensin-aldosterone system were studied one half to 3 hours later. Nifedipine reduced blood pressure and increased pulse rate in young and old persons with or without hypertension. Simultaneously, nifedipine produced a significant increase of plasma renin activity in young persons with or without hypertension but failed to do so in old persons with or without hypertension. As a result, angiotensin I and II increased significantly in young persons but not in old persons. Hydralazine elevated aldosterone concentration by stimulating the renin-angiotensin system but nifedipine failed to do so despite its effect on the renin-angiotensin system in young individuals. Since calcium is required to secrete aldosterone, it is suggested that nifedipine blocked aldosterone secretion by the agent's calcium antagonizing action.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-8703
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1346-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6293295-Adult,
pubmed-meshheading:6293295-Age Factors,
pubmed-meshheading:6293295-Aldosterone,
pubmed-meshheading:6293295-Angiotensin I,
pubmed-meshheading:6293295-Angiotensin II,
pubmed-meshheading:6293295-Blood Pressure,
pubmed-meshheading:6293295-Calcium,
pubmed-meshheading:6293295-Heart Rate,
pubmed-meshheading:6293295-Humans,
pubmed-meshheading:6293295-Hydralazine,
pubmed-meshheading:6293295-Hydrocortisone,
pubmed-meshheading:6293295-Hypertension,
pubmed-meshheading:6293295-Middle Aged,
pubmed-meshheading:6293295-Nifedipine,
pubmed-meshheading:6293295-Peptidyl-Dipeptidase A,
pubmed-meshheading:6293295-Pyridines,
pubmed-meshheading:6293295-Renin,
pubmed-meshheading:6293295-Renin-Angiotensin System
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pubmed:year |
1982
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pubmed:articleTitle |
Acute effects of the calcium antagonist, nifedipine, on blood pressure, pulse rate, and the renin-angiotensin-aldosterone system in patients with essential hypertension.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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