Linked Life Data

6292767

Source:http://linkedlifedata.com/resource/pubmed/id/6292767

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1983-1-19
pubmed:abstractText
Benzodiazepines (chlordiazepoxide and diazepam) produced a dose-dependent decrease in the discharge rate of serotonin-containing neurons in the dorsal raphe nucleus of freely moving cats. This ranged from no significant change at doses of 0.5 and 1.0 mg/kg (i.p.), to greater than 90% reductions in unit activity at 10 mg/kg. The effects of benzodiazepines on raphe units occurred within 15-30 min of injection and the duration of action was dose-dependent and lasted from 1 to more than 6 hr. Doses of benzodiazepines that significantly decreased raphe unit activity (i.e. 2.5-10 mg/kg) also produced ataxia and decreased EMG activity. These data suggest that benzodiazepine-induced suppression of raphe unit activity is closely related to general motor behavior. Raphe unit activity remained suppressed during phasic increases in EMG activity during eating, grooming, or predatory behavior, suggesting that benzodiazepines also have a direct inhibitory action on raphe cells. The present results are discussed in the context of the serotonergic hypothesis of anxiety.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1045-50
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Raphe unit activity in freely moving cats: effects of benzodiazepines.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.