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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-1-7
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pubmed:abstractText |
The voltage dependence of the conductance induced induced in thin lipid membranes by monazomycin is shown here to be caused by voltage-dependent variations in the frequency of channel openings. We also experimentally demonstrate certain interesting properties of the channel activity that are predicted by a chemical kinetic model (Muller and Peskin, 1981), which successfully describes the macroscopic conductance. We conclude that two parallel mechanisms--one autocatalytic, the other simple mass action--exist that allow monazomycin to enter (or leave) the membrane so that the monazomycin molecules can be in a position to form channels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1295
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-49
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pubmed:dateRevised |
2008-11-20
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pubmed:meshHeading |
pubmed-meshheading:6292331-Anti-Bacterial Agents,
pubmed-meshheading:6292331-Electric Conductivity,
pubmed-meshheading:6292331-Ion Channels,
pubmed-meshheading:6292331-Kinetics,
pubmed-meshheading:6292331-Lipid Bilayers,
pubmed-meshheading:6292331-Macrolides,
pubmed-meshheading:6292331-Membrane Potentials,
pubmed-meshheading:6292331-Models, Chemical,
pubmed-meshheading:6292331-Polyenes,
pubmed-meshheading:6292331-Time Factors
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pubmed:year |
1982
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pubmed:articleTitle |
Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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