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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1982-12-18
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pubmed:abstractText |
This report presents an adrenal ganglioneuroblastoma containing several kinds of neuronal peptides. The tumour was found in the autopsy case of a 3-year-old girl with clinical manifestation of intractable diarrhea, hypokalemia, achlorhydria, and with elevated levels of plasma vasoactive intestinal peptide (VIP). Immunoperoxidase staining showed many immunoreactive VIP- containing cells, some somatostatin-and substance P-containing cells on the tumour sections. Ultrastructurally, the tumour cells contained numerous secretory granules that could be divided mainly two types; one is a small cored vesicle (50-150 nm in diameter) and the other large electron dense secretory granule (200-500 nm in diameter). It was suggested that the cells in ganglioneuroblastoma derived from neural crest are closely related to the cells that could differentiate into gut-hormone-producing cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0001-6632
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
807-14
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6291317-Adrenal Gland Neoplasms,
pubmed-meshheading:6291317-Child, Preschool,
pubmed-meshheading:6291317-Diarrhea,
pubmed-meshheading:6291317-Female,
pubmed-meshheading:6291317-Ganglioneuroma,
pubmed-meshheading:6291317-Histocytochemistry,
pubmed-meshheading:6291317-Humans,
pubmed-meshheading:6291317-Immunoenzyme Techniques,
pubmed-meshheading:6291317-Microscopy, Electron,
pubmed-meshheading:6291317-Peptides,
pubmed-meshheading:6291317-Syndrome,
pubmed-meshheading:6291317-Vasoactive Intestinal Peptide,
pubmed-meshheading:6291317-Vipoma
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pubmed:year |
1982
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pubmed:articleTitle |
Ganglioneuroblastoma containing several kinds of neuronal peptides with watery diarrhea syndrome.
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pubmed:publicationType |
Journal Article,
Case Reports
|