Linked Life Data

6290235

Source:http://linkedlifedata.com/resource/pubmed/id/6290235

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1982-12-21
pubmed:abstractText
The purpose of this study was to characterize the discriminative stimulus property of dl-SKF 10,047 in the rat and to investigate if this property is the result of an interaction with opiate receptors or dopaminergic mechanisms. Male Sprague Dawley rats were trained in a two-lever food-reinforced procedure to discriminate between the effect of saline and of dl-SKF 10,047 (5 mg/kg). The trained rats dose dependently generalized the effect of dl-, d- and l-SKF 10,047, as well as cyclazocine, phencyclidine and ketamine but did not generalize the effect of either fentanyl, morphine, bremazocine, ethylketocyclazocine, pentazocine, nalorphine, naloxone, MR 2266, d-lysergic acid diethylamide, apomorphine or d-amphetamine. Neither naloxone, MR 2266, fentanyl, ethylketocyclazocine nor haloperidol antagonized the discriminative stimulus produced by dl-SKF 10,047. These data suggest that the discriminative stimulus property of dl-SKF 10,047 in the rat is not due to its interaction with either opiate receptors or dopaminergic mechanisms but may be related to its psychotomimetic effect in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't