Linked Life Data

6287607

Source:http://linkedlifedata.com/resource/pubmed/id/6287607

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
1982-10-12
pubmed:abstractText
We studied the effects on the cardiovascular system and isolated intestine of three potential antidepressants : amineptin, nomifensin and mianserin. 1) No animals died in spite of doses well above the therapeutic range, evidencing the good tolerance of the compounds. 2) Effects on heart rate were variable; the only significant effect was cardioacceleration seen with mianserin in doses above 5 mg/kg. 3) The only significant effect on the auriculoventricular refractory period was recorded with mianserin. 4) Amineptin was the only compound that increased blood pressure. 5) Auriculoventricular conduction was slowed with mianserin in doses above 10 mg/kg. 6) On isolated rat duodenum, mianserin was spasmogenic in concentrations above 100 microgram/100 ml. 7) in comparison to tricyclic antidepressants, these three compounds carry only few risks of adverse side-effects.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:author
pubmed:day
10
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1439-42
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[A study of three potential antidepressants (amineptin, mianserin and nomifensin) on the cardiovascular system and isolated intestine (author's transl)].
pubmed:publicationType
Journal Article, In Vitro, English Abstract