rdf:type |
|
lifeskim:mentions |
umls-concept:C0004793,
umls-concept:C0022722,
umls-concept:C0029016,
umls-concept:C0033684,
umls-concept:C0249197,
umls-concept:C0288472,
umls-concept:C0679058,
umls-concept:C1420626,
umls-concept:C1510411,
umls-concept:C1547699,
umls-concept:C2700640
|
pubmed:issue |
4563
|
pubmed:dateCreated |
1982-10-12
|
pubmed:databankReference |
|
pubmed:abstractText |
The transforming protein of Kirsten murine sarcoma virus (Ki-MuSV) is a virally encoded 21-kilodalton protein called p21 kis. The sequences encoding p21 kis were genetically localized to a 1.3-kilobase segment near the 5' end of the viral genome by assaying the capacity of a series of defined deletion mutants of molecularly cloned Ki-MuSV DNA to induce focal transformation of mouse cells. Nucleotide sequencing of a portion of this region has led to the identification of an open reading frame of 567 nucleotides coding for p21 kis protein.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0036-8075
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
3
|
pubmed:volume |
217
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
937-9
|
pubmed:dateRevised |
2011-11-4
|
pubmed:meshHeading |
pubmed-meshheading:6287573-Animals,
pubmed-meshheading:6287573-Base Sequence,
pubmed-meshheading:6287573-Cell Transformation, Viral,
pubmed-meshheading:6287573-Cells, Cultured,
pubmed-meshheading:6287573-DNA, Recombinant,
pubmed-meshheading:6287573-DNA, Viral,
pubmed-meshheading:6287573-DNA Restriction Enzymes,
pubmed-meshheading:6287573-Genes, Viral,
pubmed-meshheading:6287573-Kirsten murine sarcoma virus,
pubmed-meshheading:6287573-Mice,
pubmed-meshheading:6287573-Mice, Inbred BALB C,
pubmed-meshheading:6287573-Molecular Sequence Data,
pubmed-meshheading:6287573-Mutation,
pubmed-meshheading:6287573-Oncogene Protein p21(ras),
pubmed-meshheading:6287573-RNA, Viral,
pubmed-meshheading:6287573-Sarcoma Viruses, Murine,
pubmed-meshheading:6287573-Viral Proteins
|
pubmed:year |
1982
|
pubmed:articleTitle |
Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|