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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1982-10-29
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pubmed:databankReference |
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pubmed:abstractText |
The rearranged lambda 2 gene of the mouse plasmacytoma cell line MOPC315 has been cloned and sequenced. A comparison of its sequence with the sequence of the unrearranged (germ-line) V, J and C gene segments shows that the sequences of the V gene segments differ at six positions. The sequence of the J and C gene segments remained unchanged. These results add support to the hypothesis that somatic mutations occur in immunoglobulin in genes and that these mutations do not involve the C gene segment. The degree of homology of the elements of the lambda 2 gene with those of the lambda 1 gene and C lambda 3 and C lambda 4 gene fragments suggest a pathway of evolution by gene duplication of the immunoglobulin lambda light chain locus. According to this scheme the original structure V0-J0C0 gave rise to a structure V0-J1C1-J11C11 by duplication of the J0C0 region. A second duplication encompassing the whole region resulted in the present structure: V1-J3C3-J1C1/V2-J2C2-J4C4.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-100225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-103630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-106304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-115000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-4108695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-418414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-4760498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-5483159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6101208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6165998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6171827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6251474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6259534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6262318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6273429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6453743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6766210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6769593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6774258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6777049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6785724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6791160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6791832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6799835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6801657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6801658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-6804942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287422-7231520
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3831-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6287422-Animals,
pubmed-meshheading:6287422-Base Sequence,
pubmed-meshheading:6287422-Cell Line,
pubmed-meshheading:6287422-Chromosomes,
pubmed-meshheading:6287422-Cloning, Molecular,
pubmed-meshheading:6287422-DNA,
pubmed-meshheading:6287422-DNA Restriction Enzymes,
pubmed-meshheading:6287422-Genes,
pubmed-meshheading:6287422-Immunoglobulin Light Chains,
pubmed-meshheading:6287422-Immunoglobulin lambda-Chains,
pubmed-meshheading:6287422-Mice,
pubmed-meshheading:6287422-Nucleic Acid Hybridization,
pubmed-meshheading:6287422-Plasmacytoma,
pubmed-meshheading:6287422-Plasmids
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pubmed:year |
1982
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pubmed:articleTitle |
Nucleotide sequence of a chromosomal rearranged lambda 2 immunoglobulin gene of mouse.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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