|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0014644,
umls-concept:C0020792,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0449432,
umls-concept:C0475463,
umls-concept:C1179435,
umls-concept:C1273518,
umls-concept:C1515655,
umls-concept:C1524073,
umls-concept:C1542147,
umls-concept:C1548799,
umls-concept:C1705248
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1982-10-29
|
|
pubmed:abstractText |
The majority of hybridomas we have characterized against Epstein-Barr virions react with the major glycoproteins gp350 and gp220 (gp350/220). One of these antibodies, ID4C-1, neutralizes virus infection in vitro. The presence of gp350/220 on the viral envelope could be confirmed directly by immunoelectron microscopy. We used lectin affinity (ricin) and immunoaffinity (ID4C-1) to purify gp350/220 and show that this material is able to induce potent virus-neutralizing antibodies. Absorption of four human and one rabbit anti-Epstein-Barr virus sera with purified gp350/220 suggests that this is the primary component responsible for generating neutralizing antibodies in vivo.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-1102604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-11905208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-165518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-167182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-176452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-195004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-217544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-221591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-228070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-229261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-4109105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-4917014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6059570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6154378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6161964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6162806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6177865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6248876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6254017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6254073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-6268807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-89099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6287039-92577
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
730-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6287039-Animals,
pubmed-meshheading:6287039-Antibodies, Viral,
pubmed-meshheading:6287039-Burkitt Lymphoma,
pubmed-meshheading:6287039-Glycoproteins,
pubmed-meshheading:6287039-Herpesvirus 4, Human,
pubmed-meshheading:6287039-Humans,
pubmed-meshheading:6287039-Immunoenzyme Techniques,
pubmed-meshheading:6287039-Microscopy, Electron,
pubmed-meshheading:6287039-Neutralization Tests,
pubmed-meshheading:6287039-Rabbits,
pubmed-meshheading:6287039-Viral Envelope Proteins,
pubmed-meshheading:6287039-Viral Proteins
|
|
pubmed:year |
1982
|
|
pubmed:articleTitle |
Identification and isolation of the main component (gp350-gp220) of Epstein-Barr virus responsible for generating neutralizing antibodies in vivo.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
