Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-10-12
pubmed:abstractText
Depolarization-induced (potassium-stimulated) influx of 45Ca, 85Sr, and 133Ba was measured in synaptosomes prepared from rat brain. There are two phases of divalent cation entry, "fast" and "slow;" each phase is mediated by channels with distinctive characteristics. The fast channels inactivate (within 1 s) and are blocked by low concentrations (less than 1 micro M) of La. The slow channels do not inactivate (within 10 s), and are blocked by high concentrations (greater than 50 micro M) of La. Divalent cation influx through both channels saturates with increasing concentrations of permeant divalent cation; in addition, each permeant divalent cation species competitively blocks the influx of other permeant species. These results are consistent with the presence of "binding sites" for divalent cations in the fast and slow channels. The Ca:Sr:Ba permeability ratio, determined by measuring the influx of all three species in triple-label experiments, was 6:3:2 for the fast channel and 6:3:1 for the slow channel. A simple model for ion selectivity, based on the presence of a binding site in the channel, could account well for slow and, to some extent, for fast, channel selectivity data.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-103199, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-10822500, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-1182020, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-1202320, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-13449874, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-13784437, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-195042, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-238033, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-238034, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-238230, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-286336, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-291898, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-304889, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-306431, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-421841, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-4307710, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-4362638, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-4387376, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-45400, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-4575321, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-4824996, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-4885777, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-4922961, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-49421, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-5120393, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-513116, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-559759, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-5648828, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-6255142, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-6261668, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-6273532, http://linkedlifedata.com/resource/pubmed/commentcorrection/6286843-672962
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1295
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1065-87
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Influx of calcium, strontium, and barium in presynaptic nerve endings.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.