Linked Life Data

6285392

Source:http://linkedlifedata.com/resource/pubmed/id/6285392

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-9-17
pubmed:abstractText
Chronic oral treatment of young adult male Fischer rats with delta 9-tetrahydrocannabinol (THC), 1, 5 and 25 mg/kg/day, or crude marihuana extract (CME), 3, 15 and 75 mg/kg/day, suppresses growth of accessory sex organs and body weight gain in a dose-related manner. Animals pair fed with the THC (25 mg/kg) group gained slightly more in body weight than the THC group, but their relative accessory sex organ weights were intermediate between THC and ad libitum-fed control group weights. These latter differences may be due to altered serum androgen levels since these levels 2-6 h after last treatment were 0.15, 0.77 and 3.33 ng/ml for THC, pair-fed and ad libitum-fed groups, respectively. 24 h after the last treatment all groups were within normal levels. Thus, chronic cannabinoid treatment suppresses accessory sex organ weights and serum androgen levels greater than the suppression caused by reduced food intake alone.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-7012
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-13
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effects of cannabinoids given orally and reduced appetite on the male rat reproductive system.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.