Linked Life Data

6285297

Source:http://linkedlifedata.com/resource/pubmed/id/6285297

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1982-9-24
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00487, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00489, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00490, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00503, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00504, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00505, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00506, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00507, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00508, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00509, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00511, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00512, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00513, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00514
pubmed:abstractText
Five closely related immunoglobulin VH genes (subgroup II) were compared by sequencing of several kb of DNA. In three of the genes homology greater than 75% was found along an area of 4 kb that includes the coding region. The homology in flanking regions is only slightly lower than that in the coding sequences. Two other genes, which are located on the same EcoRI fragment, show high homology to the first three genes in the coding and immediately flanking regions. In more distant flanking regions no homology is found with the first three genes. This indicates that their evolutionary history differs from that of the other three genes. A region of simple DNA sequence composed of repetitive TCC and TCA elements was found at a distance of approximately 380 bp upstream from the initiator ATG of these VH genes. This region is the site where the two sets of genes abruptly start to diverge. The structure of the simple DNA sequence in the various VH genes suggests that it may be involved in gene interaction. We propose that both simple DNA sequences and homology in flanking regions serve a function in the correction of VH genes, which seem to be rather free to diverge and drift into pseudogenes. A correction mechanism may help this gene family to maintain its two major features, multiplicity and diversity.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-103630, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-1105573, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-111144, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-112914, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-115000, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-1195397, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-265521, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-322279, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-344137, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-384000, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6101208, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6159575, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6253904, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6255443, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-631324, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6446404, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6766210, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6767191, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6767723, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6769593, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6774258, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6779204, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6787590, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6788376, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6789211, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6791833, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-688387, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6929543, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-6985477, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-7010180, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-7018693, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-728984, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-7407925, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-7438203, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-787539, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-787937, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-813561, http://linkedlifedata.com/resource/pubmed/commentcorrection/6285297-99815
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3353-70
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
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