| pubmed-article:6284643 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C2338991 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C0023767 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:6284643 | lifeskim:mentions | umls-concept:C0142328 | lld:lifeskim |
| pubmed-article:6284643 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6284643 | pubmed:dateCreated | 1982-9-24 | lld:pubmed |
| pubmed-article:6284643 | pubmed:abstractText | To establish the requirements for a potential subunit vaccine against herpes simplex virus (HSV), we analyzed the effects on immunogenicity of incorporating detergent-extracted glycoprotein-enriched HSV type 1 (HSV-1) antigens into liposomes alone or with the adjuvant lipid A. Incorporating HSV-1 antigens into liposomes enhanced their immunogenicity for antibody production as detected by radioimmunoassay. Antibody levels to free and liposome-bound antigens were enhanced by administering lipid A as an adjuvant. The maximum immunogenic effect was obtained by incorporating lipid A into liposomes containing the HSV-1 proteins. Such liposomes induced secondary antibody responses higher than those engendered by virus infection. Whereas infectious virus induced cell-mediated immunity detectable by the delayed-type hypersensitivity reactions and cytotoxic T lymphocyte production, none of the liposome preparations induced cell-mediated immunity. | lld:pubmed |
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| pubmed-article:6284643 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6284643 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6284643 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6284643 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6284643 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:6284643 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:6284643 | pubmed:author | pubmed-author:RouseB TBT | lld:pubmed |
| pubmed-article:6284643 | pubmed:author | pubmed-author:HuangLL | lld:pubmed |
| pubmed-article:6284643 | pubmed:author | pubmed-author:NaylorP TPT | lld:pubmed |
| pubmed-article:6284643 | pubmed:author | pubmed-author:LarsenH SHS | lld:pubmed |
| pubmed-article:6284643 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6284643 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:6284643 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6284643 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6284643 | pubmed:pagination | 1209-16 | lld:pubmed |
| pubmed-article:6284643 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:6284643 | pubmed:meshHeading | pubmed-meshheading:6284643-... | lld:pubmed |
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| pubmed-article:6284643 | pubmed:meshHeading | pubmed-meshheading:6284643-... | lld:pubmed |
| pubmed-article:6284643 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6284643 | pubmed:articleTitle | In vivo induction of anti-herpes simplex virus immune response by type 1 antigens and lipid A incorporated into liposomes. | lld:pubmed |
| pubmed-article:6284643 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6284643 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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