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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1982-9-24
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pubmed:abstractText |
To establish the requirements for a potential subunit vaccine against herpes simplex virus (HSV), we analyzed the effects on immunogenicity of incorporating detergent-extracted glycoprotein-enriched HSV type 1 (HSV-1) antigens into liposomes alone or with the adjuvant lipid A. Incorporating HSV-1 antigens into liposomes enhanced their immunogenicity for antibody production as detected by radioimmunoassay. Antibody levels to free and liposome-bound antigens were enhanced by administering lipid A as an adjuvant. The maximum immunogenic effect was obtained by incorporating lipid A into liposomes containing the HSV-1 proteins. Such liposomes induced secondary antibody responses higher than those engendered by virus infection. Whereas infectious virus induced cell-mediated immunity detectable by the delayed-type hypersensitivity reactions and cytotoxic T lymphocyte production, none of the liposome preparations induced cell-mediated immunity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-13813473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-14450081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-217506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-240860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-265565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-310517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-311343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-334973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-334974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-392087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-411630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-4367302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-448082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-47220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-489132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-5010391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-5804498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-6244225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-6245140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-6274793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-641340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-6969745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-6971170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-7000672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-7014445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-7399568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6284643-825573
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1209-16
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6284643-Adjuvants, Immunologic,
pubmed-meshheading:6284643-Animals,
pubmed-meshheading:6284643-Antibodies, Viral,
pubmed-meshheading:6284643-Antigens, Viral,
pubmed-meshheading:6284643-Female,
pubmed-meshheading:6284643-Lipid A,
pubmed-meshheading:6284643-Liposomes,
pubmed-meshheading:6284643-Mice,
pubmed-meshheading:6284643-Simplexvirus
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pubmed:year |
1982
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pubmed:articleTitle |
In vivo induction of anti-herpes simplex virus immune response by type 1 antigens and lipid A incorporated into liposomes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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