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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1982-8-7
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pubmed:abstractText |
To provide a definite basis for studies on the biological effects of exogenously administered catecholestrogens, the time courses of the concentrations of these estrogens in serum, pituitary and CNS-tissues were studied in male rats after s.c. injection of either 150 microgram of 4-hydroxyestradiol or 2-hydroxyestradiol (dissolved in 200 microliter sesame oil/ethanol/ascorbic acid; 97.5/2.5/0.1; vol/vol/wt) or equimolar amounts of 4-hydroxyestradiol 3, 4-dibenzoate or 2-hydroxyestradiol 2,3-dibenzoate (dissolved in 200 microliter sesame oil). The injection of free catecholestrogens resulted in bolus-like elevations of the serum and tissue concentrations of the respective compound (max. values up to 9 ng/ml, half-life below 1 h) whereas the injection of catecholestrogen benzoates gave lower (max. values about 1 ng/ml) but prolonged elevations (half-life approx. 24 h and 32 h for 4-OHE2 and 2-OHE2) of the respective free catecholestrogen.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
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pubmed:issn |
0039-128X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
39
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
291-300
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6283699-Animals,
pubmed-meshheading:6283699-Estrogens, Catechol,
pubmed-meshheading:6283699-Kinetics,
pubmed-meshheading:6283699-Male,
pubmed-meshheading:6283699-Pituitary Gland,
pubmed-meshheading:6283699-Rats,
pubmed-meshheading:6283699-Rats, Inbred Strains,
pubmed-meshheading:6283699-Time Factors
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pubmed:year |
1982
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pubmed:articleTitle |
Pharmacokinetics of free catecholestrogens and catecholestrogen benzoates.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|