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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1982-8-26
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pubmed:abstractText |
Thirty male alcoholic inpatients received in a random double-blind design placebo (P) or disulfiram 250 mg. (D) at bedtime in order to evaluate the effects of the latter on EEG-EOG sleep patterns. Subjects (S's) had no major medical illness and required no medication for 3 weeks prior to the study. There were 13 disulfiram S's and 17 placebo S's. The total REM time decreased significantly (p less than 0.05) in the D group. Total number of REM episodes decreased and latency to stage 1 REM increased in the disulfiram group. These results are characteristic of sleep patterns induced by the administration of catecholaminergics and opposite to those induced by catecholamine inhibiting agents.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0161-8504
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
159-66
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6282542-Adult,
pubmed-meshheading:6282542-Alcoholism,
pubmed-meshheading:6282542-Animals,
pubmed-meshheading:6282542-Cats,
pubmed-meshheading:6282542-Disulfiram,
pubmed-meshheading:6282542-Dopamine,
pubmed-meshheading:6282542-Double-Blind Method,
pubmed-meshheading:6282542-Ethanol,
pubmed-meshheading:6282542-Humans,
pubmed-meshheading:6282542-Male,
pubmed-meshheading:6282542-Middle Aged,
pubmed-meshheading:6282542-Norepinephrine,
pubmed-meshheading:6282542-Random Allocation,
pubmed-meshheading:6282542-Rats,
pubmed-meshheading:6282542-Receptors, Adrenergic,
pubmed-meshheading:6282542-Sleep,
pubmed-meshheading:6282542-Sleep, REM
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pubmed:year |
1981
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pubmed:articleTitle |
Effects of disulfiram on the sleep of chronic alcoholics.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial
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