Linked Life Data

6281610

Source:http://linkedlifedata.com/resource/pubmed/id/6281610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-7-22
pubmed:abstractText
This report describes the detailed time-course of in vitro net mass transfers of esterified cholesterol (EC) and triglyceride (TG) between human plasma lipoproteins incubated in the presence of EC and TG transfer proteins. In incubations containing high density lipoproteins (HDL), very low density lipoproteins (VLDL) and the thiol-group blocker parachloromercuriphenyl sulfonate (PCMPS) (which was added to inhibit EC production), the rate of EC transfer to VLDL was considerably more rapid than that of TG to HDL and equilibrium between the pools of EC was achieved much sooner than was the case for the pools of TG. When VLDL and low density lipoproteins (LDL) were incubated, the presence of PCMPS in the incubation mixture resulted in a marked reduction in the TG transfer to LDL, even though the EC transfer to VLDL was apparently unaffected. The molar ratio of the transfers of EC and TG was also examined in incubations of lipoproteins from a variety of human subjects. In incubations of HDL and VLDL (performed in the absence of PCMPS) there was a large individual variation (sixfold difference) in the molar ratio of the transfers of TG:EC. In incubations of LDL and VLDL from different subjects there was a twofold individual variation in the molar ratio of the transfers of TG:EC. It has been concluded that the net mass transfers of EC and TG between human lipoproteins do not involve a simple molecular exchange of one moiety for the other, as has been suggested previously, but are achieved by processes which are at least partially independent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0026-0495
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-81
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Dissociation of the in vitro transfers of esterified cholesterol and triglyceride between human lipoproteins.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't