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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1982-7-19
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pubmed:abstractText |
The pathogenesis and prevention of generalized infection and interstitial pneumonia due to cytomegalovirus (CMV) in inbred strain 2 guinea pigs were investigated. Eighteen animals inoculated with approximately 10(7) 50% tissue culture infective doses of virulent salivary gland-passaged guinea pig CMV (GPCMV-SG) developed generalized, viremic CMV infections, and 44% of the animals died. Most (68%) cocultivated tissues showed CMV infection, including lungs, which demonstrated severe bilateral interstitial pneumonia. Guinea pigs inoculated with live tissue culture-passaged GPCMV (GPCMV-TC) vaccine developed mild, nonlethal, generalized CMV infections and minimal histopathologic changes in infected tissues, including lungs. After challenge of 19 GPCMV-TC-vaccinated animals with GPCMV-SG, viremia was detectable in two (11%); CMV was detected in 15% of cocultivated tissues and rarely in lungs. Although vaccinated animals showed histologic evidence of interstitial pneumonia after challenge, none died. Strain 2 guinea pigs are useful for studies of pathogenesis and prevention of generalized CMV infection, particularly CMV-associated interstitial pneumonia.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
742-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6281341-Animals,
pubmed-meshheading:6281341-Cytomegalovirus,
pubmed-meshheading:6281341-Cytomegalovirus Infections,
pubmed-meshheading:6281341-Female,
pubmed-meshheading:6281341-Guinea Pigs,
pubmed-meshheading:6281341-Immunity,
pubmed-meshheading:6281341-Lung,
pubmed-meshheading:6281341-Male,
pubmed-meshheading:6281341-Pulmonary Fibrosis,
pubmed-meshheading:6281341-Vaccination,
pubmed-meshheading:6281341-Viral Vaccines
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pubmed:year |
1982
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pubmed:articleTitle |
Effects of vaccination on cytomegalovirus-associated interstitial pneumonia in strain 2 guinea pigs.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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