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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1982-6-14
|
| pubmed:abstractText |
Incubation of 20,000 xg supernatants of liver homogenates from female Wistar rats with benzo(a)pyrene (BP) and other cofactors in the presence of coenzyme A (CoA) produced metabolites that required extensive hydrolysis successively in 2N NaOH, 2N HCl, 2N NaOH and 6N HCl for their release. It is suggested that coenzyme A activated benzpyrenyl-amino acid formed via epoxide(s). The activated amino acid(s) became bound to thiol protein.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0034-5164
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
329-32
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6280258-Animals,
pubmed-meshheading:6280258-Benzo(a)pyrene,
pubmed-meshheading:6280258-Benzopyrenes,
pubmed-meshheading:6280258-Coenzyme A,
pubmed-meshheading:6280258-Female,
pubmed-meshheading:6280258-Liver,
pubmed-meshheading:6280258-Mass Spectrometry,
pubmed-meshheading:6280258-Protein Binding,
pubmed-meshheading:6280258-Rats,
pubmed-meshheading:6280258-Rats, Inbred Strains
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Influence of coenzyme A on the in vitro binding of benzo(a)pyrene metabolites to protein.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|