Linked Life Data

6280115

Source:http://linkedlifedata.com/resource/pubmed/id/6280115

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-6-24
pubmed:abstractText
A presynaptic inhibitory role for opioid peptides in the control of C-fibre-evoked activity in the dorsal horn has been investigated. The excitability of C-fibre terminals in the dorsal horn of decerebrate spinal rats was tested using intraspinal terminal stimulation and recording the size of the antidromic C wave from the dorsal roots. Naloxone (1-2 mg/kg) failed to alter the baseline terminal excitability of the C-fibres, but reduced the increase in terminal excitability produced by A-fibre afferent conditioning stimuli. The inhibition of postsynaptic C-evoked activity in lamina 5 cells produced by A-afferent fibre conditioning stimuli was also reduced by naloxone. This effect may reflect the reversal of an opioid-mediated presynaptic inhibition, although blockade of a direct postsynaptic inhibitory action could also be involved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Do opioid peptides mediate a presynaptic control of C-fibre transmission in the rat spinal cord?
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't