Linked Life Data

6278488

Source:http://linkedlifedata.com/resource/pubmed/id/6278488

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1982-5-21
pubmed:abstractText
The presence and location of DNA sequences related to the U3 and U5 portions of the infectious exogenous feline leukemia virus (FeLV) long terminal repeat (LTR) in various cat DNAs have been determined by hybridization experiments. In uninfected cat DNAs, the U5 LTR segment from the Gardner-Arnstein strain B virus is present at approximately 150 copies per cell. This level is approximately 10-fold greater than that of endogenous internal FeLV sequences. The U5 sequences differ in copy number and, to some extent, in location from one animal to another. For any one animal, the sequence organization of the U5 segments is the same among different tissues, showing that the pattern is inherited through the germ line. Most importantly, the viral U3 LTR probe hybridizes only very weakly with uninfected cat DNAs. Both the U3 and the U5 regions of the LTR from the Gardner-Arnstein strain of virus cross-hybridize with DNA derived from four other infectious FeLVs representing A, B, and C subtypes. Thus, the C3 region may be used as a probe for studying the number and location of exogenously acquired FeLV proviruses in infected cat tissues. In some cases exogenously acquired proviruses are present in unique sites in the genome of virus-positive cat lymphosarcomas, indicating a monoclonal origin for the tumor. In other tumors, the proviral sequences are randomly distributed over many sites. Lymphosarcomas of virus-negative cats have no exogenous U3 sequences despite epidemiological evidence of an association of virus-negative leukemia with exposure to FeLV.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-159209, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-210130, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-4800279, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-52892, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-57665, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6243723, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6246254, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6247824, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6251969, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6253821, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6255412, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6261142, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6264136, http://linkedlifedata.com/resource/pubmed/commentcorrection/6278488-6267771
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7778-82
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The U3 portion of feline leukemia virus DNA identifies horizontally acquired proviruses in leukemic cats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't