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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1982-4-20
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pubmed:abstractText |
The effect of a long-acting analogue of Met-enkephalin (Damme) and naloxone on anterior pituitary hormone secretion has been investigated in 14 acromegalic patients. Damme produced a progressive fall in circulating LH and cortisol and stimulated prolactin release in normoprolactinaemic patients. Naloxone infusion significantly stimulated gonadotrophin and cortisol secretion without modifying basal prolactin release both in normo-and hyperprolactinamic patients. GH levels remained unchanged during naloxone and Damme infusion. The data suggest that endogenous opiate receptors do not play a major role in modulating GH hypersecretion in acromegaly.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/D-Ala(2),MePhe(4),Met(0)-ol-enkephal...,
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Hormones, Anterior,
http://linkedlifedata.com/resource/pubmed/chemical/Prolactin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-0163
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
88-98
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6276286-Acromegaly,
pubmed-meshheading:6276286-Adult,
pubmed-meshheading:6276286-D-Ala(2),MePhe(4),Met(0)-ol-enkephalin,
pubmed-meshheading:6276286-Endorphins,
pubmed-meshheading:6276286-Enkephalins,
pubmed-meshheading:6276286-Female,
pubmed-meshheading:6276286-Follicle Stimulating Hormone,
pubmed-meshheading:6276286-Growth Hormone,
pubmed-meshheading:6276286-Hormones,
pubmed-meshheading:6276286-Humans,
pubmed-meshheading:6276286-Hydrocortisone,
pubmed-meshheading:6276286-Luteinizing Hormone,
pubmed-meshheading:6276286-Male,
pubmed-meshheading:6276286-Middle Aged,
pubmed-meshheading:6276286-Naloxone,
pubmed-meshheading:6276286-Pituitary Hormones, Anterior,
pubmed-meshheading:6276286-Prolactin,
pubmed-meshheading:6276286-Receptors, Opioid,
pubmed-meshheading:6276286-Thyrotropin
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pubmed:year |
1981
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pubmed:articleTitle |
Effects of a Met-enkephalin analogue and naloxone infusion on anterior pituitary hormone secretion in acromegaly.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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