Linked Life Data

6275494

Source:http://linkedlifedata.com/resource/pubmed/id/6275494

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-3-22
pubmed:abstractText
Intraduodenal infusion of glucose increased the concentration of pancreatic polypeptide (PP) in serum from 13.4 (4.0-20.4) to 36.9 (20.7-81.3) pM. Alpha blockade with phentolamine increased the PP concentration from 15.0 (4.0-23.7) to 24.9 (4.6-50.2) pM, and after intraduodenal glucose to 46.8 (23.6-132.8) pM. The PP release after intraduodenal glucose was small, transient, and significantly reduced when beta blockade with propranolol was administered. Oral glucose increased the concentration of PP from 19.3 (4.2-37.0) to 61.1 (14.1-141.7) pM. Isoprenaline increased the PP concentration from 13.5 (4.6-33.8) to 56.0 (5.7-137.3) pM, and after oral glucose to 77.5 (25.3-134.7) pM. The increase in PP concentration was eliminated when propranolol was added to isoprenaline. We conclude that an intestinal phase of PP release exists after intraduodenal glucose in healthy humans, and that the PP release after intraduodenal and oral glucose can be modified by the adrenergic nervous system. Alpha blockade stimulates the PP cell; beta blockade or stimulation respectively inhibits or stimulates the PP cell.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0036-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
781-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Adrenergic modulation of the release of pancreatic polypeptide after intraduodenal and oral glucose in man.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't