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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1982-3-26
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pubmed:abstractText |
The effects of treatment with varying doses of abrin, a D-galactose binding lectin, on DNA and protein synthesis of normal and Epstein Barr virus-transformed lymphocytes have been investigated. Using data on EBV-transformed lymphocyte cell density as a function of time and dose of abrin, one can demonstrate that the mean number of sites bound/EBV-lymphocyte needed to exert a biological influence upon the cell DNA synthesis lies between 59,264 and 370,000 sites/cell. Using a simple packing model, one can demonstrate that a theoretical estimate places the number of binding sites between 57,600 and 360,000 sites/cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0304-3568
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
327-31
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6274718-Abrin,
pubmed-meshheading:6274718-Binding Sites,
pubmed-meshheading:6274718-Cells, Cultured,
pubmed-meshheading:6274718-DNA,
pubmed-meshheading:6274718-Dose-Response Relationship, Drug,
pubmed-meshheading:6274718-Herpesvirus 4, Human,
pubmed-meshheading:6274718-Humans,
pubmed-meshheading:6274718-Lymphocyte Activation,
pubmed-meshheading:6274718-Lymphocytes,
pubmed-meshheading:6274718-Models, Biological,
pubmed-meshheading:6274718-Plant Proteins,
pubmed-meshheading:6274718-Receptors, Drug,
pubmed-meshheading:6274718-Time Factors
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pubmed:year |
1981
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pubmed:articleTitle |
Studies on the toxicity and binding kinetics of abrin in normal and Epstein Barr virus-transformed lymphocyte culture-I: experimental results - 3.
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pubmed:publicationType |
Journal Article
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