Linked Life Data

6273631

Source:http://linkedlifedata.com/resource/pubmed/id/6273631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-2-22
pubmed:abstractText
The relation between precursors and restoration of A-form MAO activity in rat liver after administration of clorgyline to rats was investigated by measuring the rates of recovery of A-form MAO activity after treatment with the inhibitor. The half-lives of mitochondrial and microsomal A-form MAO were estimated as 3.5 and 2.0 days, respectively. MAO activity and the amount of MAO molecules were completely restored within 14 days. However the values attained did not exceed the control values in a period of 14 days. Clorgyline plus cycloheximide or chloramphenicol did not prevent the recovery of MAO activity in the microsomes, but did not delay the appearance of enzyme activity in the mitochondria. A and B-form-like MAO were also observed in the microsomal and supernatant fractions, with clorgyline as inhibitor. These results suggest that the microsomal enzyme is a precursor of the mitochondrial enzyme, that the levels of A-form and B-form MAO are regulated genetically, and that the two forms of MAO may be synthesized separately.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-5198
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
763-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Further studies on the synthesis of A-form monoamine oxidase.
pubmed:publicationType
Journal Article, In Vitro