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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1982-2-22
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pubmed:abstractText |
Four steroids and one protease inhibitor were evaluated for their effects on 12-O-tetradecanoyl phorbol 13-acetate (TPA)-induced and Epstein-Barr virus-induced early antigens (EBV-EA) in Raji cells. Continuous treatment with dexamethasone, prednisolone, hydrocortisone and cortisone inhibited TPA-induced EBV-EA to varying degrees, but the protease inhibitor N-alpha-p-tosyl L-lysine chloromethyl ketone-HCl (TLCK) had no significant effect. None of the agents tested inhibited EBV- induced EA. In addition, the effect of the steroids was reversible since the removal of these agents resulted in recovery of the percentage of EBV-EA-positive cells in TPA-treated cultures. These results were in agreement with the in vivo experiments of other investigators, who demonstrated inhibition of tumor promotion with steroids. Since TLCK failed to inhibit TPA-induced EA, it is unlikely that induction of EA by TPA is the result of production of proteases.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenal Cortex Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbols,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Tosyllysine Chloromethyl Ketone
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0020-7136
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
503-7
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:6273335-Adrenal Cortex Hormones,
pubmed-meshheading:6273335-Antigens, Viral,
pubmed-meshheading:6273335-B-Lymphocytes,
pubmed-meshheading:6273335-Burkitt Lymphoma,
pubmed-meshheading:6273335-Cell Line,
pubmed-meshheading:6273335-Cell Transformation, Viral,
pubmed-meshheading:6273335-Herpesvirus 4, Human,
pubmed-meshheading:6273335-Humans,
pubmed-meshheading:6273335-Phorbols,
pubmed-meshheading:6273335-Tetradecanoylphorbol Acetate,
pubmed-meshheading:6273335-Tosyllysine Chloromethyl Ketone
|
pubmed:year |
1981
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pubmed:articleTitle |
Steroids inhibit tumor promoting agent induced Epstein-Barr virus early antigens in Raji cells.
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pubmed:publicationType |
Journal Article
|