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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1982-2-22
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pubmed:abstractText |
Colony forming unit (CFU) assays were developed for feline granulocyte-macrophage (CFUGM), early erythroid (day 2 CFUE), and late erythroid (day 7 CFUE) colonies in methylcellulose medium. Feline CFUGM and both day 2 and day 7 CFUE were enhanced by feline macrophage conditioned medium and late CFUE often were intimately associated with macrophages. Kittens were inoculated with the Kawakami-Theilen (KT) strain of feline leukemia virus (FeLV) and sequential changes in marrow CFU determined. Erythroid aplasia, characterized by progressive non-regenerative anemia, lymphopenia, and a profound decrease in early and late CFUE but not CFUGM was induced by 3 to 5 weeks after FeLV-KT inoculation. The susceptibility of kittens to FeVL-induced erythroid aplasia was strongly age-related; neonatal kittens were most sensitive and substantial natural resistance developed by 4 weeks of age. The results demonstrate that FeLV-KT infection induced a rapid and selective suppression of erythroid progenitor cells and represents a suitable model of experimentally-induced acquired erythroid aplasia.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0301-472X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
9
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
990-1001
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6273200-Anemia, Aplastic,
pubmed-meshheading:6273200-Animals,
pubmed-meshheading:6273200-Animals, Newborn,
pubmed-meshheading:6273200-Bone Marrow Cells,
pubmed-meshheading:6273200-Cats,
pubmed-meshheading:6273200-Colony-Forming Units Assay,
pubmed-meshheading:6273200-Erythrocytes,
pubmed-meshheading:6273200-Hematopoietic Stem Cells,
pubmed-meshheading:6273200-Leukemia Virus, Feline,
pubmed-meshheading:6273200-Time Factors
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pubmed:year |
1981
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pubmed:articleTitle |
Feline leukemia virus-induced erythroid aplasia: in vitro hemopoietic culture studies.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|