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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11 Pt 1
|
| pubmed:dateCreated |
1982-2-22
|
| pubmed:abstractText |
Two patients with Hodgkin's disease in remission and one chronic lymphatic leukemia patient with extraordinarily high anti-Epstein-Barr virus (EBV) (viral capsid antigen) antibody titers (greater than 10,000) were selected to study a spectrum of cell-mediated immune responses, including natural killer, interferon-boosted killer, antibody-dependent lymphocytotoxicity, and T-cell-mediated reactions. The purpose was to compare these reactions in patients with immunosuppression and a high EBV load who can hold their EBV-carrying cells under control with the corresponding reactions in patients with EBV-carrying lymphoproliferative disease. In contrast to the latter group, the three patients of the present study showed a less profound and less general suppression of the immune responses. Multiple effector mechanisms probably safeguard against the proliferation of EBV-transformed B-cells. Clinically manifest EBV-carrying lymphoproliferative disease occurs only in very severe immunodeficiencies effecting multiple effectors.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0008-5472
|
| pubmed:author |
pubmed-author:BjörkholmMM,
pubmed-author:ErnbergII,
pubmed-author:HenleGG,
pubmed-author:HenleWW,
pubmed-author:JohanssonBB,
pubmed-author:KleinGG,
pubmed-author:MasucciGG,
pubmed-author:MasucciM GMG,
pubmed-author:MellstedtHH,
pubmed-author:PearsonGG,
pubmed-author:SvedmyrEE,
pubmed-author:SzigetiRR
|
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4292-301
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6272973-Adolescent,
pubmed-meshheading:6272973-Adult,
pubmed-meshheading:6272973-Aged,
pubmed-meshheading:6272973-Animals,
pubmed-meshheading:6272973-Antibodies, Viral,
pubmed-meshheading:6272973-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:6272973-Capsid,
pubmed-meshheading:6272973-Cell Line,
pubmed-meshheading:6272973-DNA, Viral,
pubmed-meshheading:6272973-Female,
pubmed-meshheading:6272973-Herpesvirus 4, Human,
pubmed-meshheading:6272973-Hodgkin Disease,
pubmed-meshheading:6272973-Humans,
pubmed-meshheading:6272973-Immunity, Cellular,
pubmed-meshheading:6272973-Leukemia, Lymphoid,
pubmed-meshheading:6272973-Lymphocytes,
pubmed-meshheading:6272973-Male,
pubmed-meshheading:6272973-Tumor Virus Infections
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Cell-mediated immune reactions in three patients with malignant lymphoproliferative diseases in remission and abnormally high Epstein-Barr virus antibody titers.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|