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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1982-1-20
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pubmed:abstractText |
This study compared the electrophysiological effects of locally applied cyclic adenosine-mono-phosphate (N6cAMP) between Purkinje neurons from young (4-month) and old rats (15-months and older). Purkinje neurons from young rats were significantly more sensitive to locally applied norepinephrine and N6cAMP than neurons from old rats. GABA sensitivity between the two groups was unaltered. Our results suggest that the locus of the adrenergic subsensitivity observed in older animals may reside to a large extent at or beyond the level of cAMP generation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0197-4580
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6272145-Aging,
pubmed-meshheading:6272145-Animals,
pubmed-meshheading:6272145-Cerebellum,
pubmed-meshheading:6272145-Cyclic AMP,
pubmed-meshheading:6272145-Male,
pubmed-meshheading:6272145-Norepinephrine,
pubmed-meshheading:6272145-Purkinje Cells,
pubmed-meshheading:6272145-Rats,
pubmed-meshheading:6272145-Rats, Inbred Strains,
pubmed-meshheading:6272145-Synaptic Transmission
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pubmed:year |
1981
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pubmed:articleTitle |
Changes in noradrenergic neurotransmission in rat cerebellum during aging.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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