Linked Life Data

6267671

Source:http://linkedlifedata.com/resource/pubmed/id/6267671

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-10-14
pubmed:abstractText
Thin strips of lung parenchyma from guinea pigs were mounted in an isolated tissue bath and placed under an initial tension of 1.2 gm. Drug-induced changes in resting tension were recorded isometrically upon the addition of representative alpha- and beta-adrenergic agonists. Lung strips relaxed following challenge with isoproterenol, 10(-9) to 10(-6)M (beta-adrenergic agonist), and contracted following challenge with phenylephrine, 10(-6) to 10(-4)M (alpha-adrenergic agonist). The responses of lung strips to norepinephrine, 10(-8) to 10(-4)M (mixed alpha- or beta-agonist) were influenced by the presence of either an alpha- or beta-adrenergic antagonist: pretreatment with phentolamine, 10(-5)M (alpha-antagonist) resulted in relaxant responses to norepinephrine, whereas pretreatment with propranolol, 10(-5)M (beta-antagonist) resulted in contractile responses. Cocaine, an uptake-1 inhibitor, potentiated the contractile effect of norepinephrine but not the relaxant effect of isoproterenol or norepinephrine. These data support the existence of alpha- and beta-adrenergic receptors mediating contraction and relaxation, respectively, in guinea pig lungs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
459-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Alpha- and beta-adrenergically mediated responses in isolated lung strips of guinea pigs.
pubmed:publicationType
Journal Article, In Vitro