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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1981-10-29
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pubmed:abstractText |
We consider the estimation of the genetic variation in a natural population when the data are obtained by the use of restriction endonucleases. Under the restriction endonuclease technique, a particular DNA segment is considered and cut wherever a recognition sequence appropriate to the endonuclease occurs. We consider data generated when a random sample of homologous DNA segments is treated in this way with one or a battery of restriction endonucleases. The numbers and sizes of the fragments that result indicate the locations and the frequencies of the recognition sequence (or, with a battery of restriction endonucleases, of each recognition sequence). These frequencies in the sample form the basis for an estimate of the amount of genetic variation in the population.
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pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0027-8424
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3748-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6267603-DNA,
pubmed-meshheading:6267603-DNA Restriction Enzymes,
pubmed-meshheading:6267603-Genetic Variation,
pubmed-meshheading:6267603-Globins,
pubmed-meshheading:6267603-Heterozygote,
pubmed-meshheading:6267603-Humans,
pubmed-meshheading:6267603-Molecular Weight,
pubmed-meshheading:6267603-Polymorphism, Genetic
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pubmed:year |
1981
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pubmed:articleTitle |
Estimation of genetic variation at the DNA level from restriction endonuclease data.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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