| pubmed-article:6267104 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6267104 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6267104 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:6267104 | lifeskim:mentions | umls-concept:C0001479 | lld:lifeskim |
| pubmed-article:6267104 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:6267104 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6267104 | pubmed:dateCreated | 1981-10-25 | lld:pubmed |
| pubmed-article:6267104 | pubmed:abstractText | To evaluate the effects of glucocorticoids on the Na-K pump in human subjects, were evaluated the intracellular sodium and potassium, 42K influx across and the [3H]ouabain binding to cell membranes of intact human erythrocytes from a group of subjects taking glucocorticoids and a group of normal subjects. Intracellular sodium concentration was lower (7.2 +/- 0.4 vs. 10.9 +/- 0.2 mmol/liter cell water) and intracellular potassium concentration higher (149.8 +/- 1.5 vs. 137.2 +/- 1.2 mmol/liter cell water) in erythrocytes from steroid-treated patients. In spite of a significantly decrease intracellular sodium which normally diminishes ouabain-sensitive 42K influx, the ouabain-sensitive K influx was unchanged in erythrocytes from the steroid-treated group. Maximum [3H]ouabain binding was markedly higher in the steroid-treated group (835 +/- 44 vs. 449 +/- 11 sites/cell). There was close linear correlation between [3H]ouabain binding and inhibition of K pump, suggesting the specificity of ouabain binding to Na-K pump sites on the cell membrane. Association kinetics for ouabain were similar in the two groups despite the marked difference in the amount of [3H]ouabain binding. External potassium concentration required for half-maximum ouabain-sensitive K influx was identical in the two groups. Thus, the additional Na-K pump sites in the steroid-treated group were qualitatively similar to those in normals. These results suggest that administration of glucocorticoids leads to an increase in the number of Na-K pump sites. The increase in the number of Na-K pump sites may explain the low levels of intracellular sodium and higher cell potassium observed in steroid-treated subjects. | lld:pubmed |
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| pubmed-article:6267104 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6267104 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6267104 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6267104 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6267104 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6267104 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:6267104 | pubmed:author | pubmed-author:KahnTT | lld:pubmed |
| pubmed-article:6267104 | pubmed:author | pubmed-author:LORDO BOB | lld:pubmed |
| pubmed-article:6267104 | pubmed:author | pubmed-author:ThakkarUU | lld:pubmed |
| pubmed-article:6267104 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6267104 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:6267104 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6267104 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6267104 | pubmed:pagination | 422-30 | lld:pubmed |
| pubmed-article:6267104 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6267104 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6267104 | pubmed:articleTitle | Glucocorticoid-induced alterations in the sodium potassium pump of the human erythrocyte. | lld:pubmed |
| pubmed-article:6267104 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6267104 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:6267104 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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