rdf:type |
|
lifeskim:mentions |
umls-concept:C0013790,
umls-concept:C0013806,
umls-concept:C0027908,
umls-concept:C0031327,
umls-concept:C0036572,
umls-concept:C0205263,
umls-concept:C0205341,
umls-concept:C0597357,
umls-concept:C0599682,
umls-concept:C1280500,
umls-concept:C1524059,
umls-concept:C1882598,
umls-concept:C2603343
|
pubmed:issue |
4
|
pubmed:dateCreated |
1981-9-15
|
pubmed:abstractText |
There is evidence that repeated electroconvulsive shocks (ECS) in rats potentiate dopamine (DA)-, serotonin (5HT)- and alpha-noradrenergic (alpha-NA)-mediated drug-induced behaviour and reduce opiate-induced behaviours. These studies suggest changes at the level of the receptor or beyond. However, high affinity in vitro 3H-ligand binding studies in brain membranes from ECS-treated control rats failed to demonstrate generalized ECS-induced changes in 5HT, DA, alpha-NA or opiate receptor binding. Binding of the beta-receptor ligand dihydroalprenolol (3H-DHA) was significantly reduced in ECS-treated rat brain membranes. This may be secondary to effects on NA neurones since ECS-induced reduction of 3H-DHA binding did not occur in animals with 6-hydroxydopamine-induced depletion of cortical noradrenaline. In conjunction with other studies, the results suggest that electroconvulsive therapy may have a noradrenergic mechanism of action.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0033-3158
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
73
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
345-9
|
pubmed:dateRevised |
2003-11-14
|
pubmed:meshHeading |
pubmed-meshheading:6265964-Animals,
pubmed-meshheading:6265964-Brain Chemistry,
pubmed-meshheading:6265964-Dihydroalprenolol,
pubmed-meshheading:6265964-Electroconvulsive Therapy,
pubmed-meshheading:6265964-Levodopa,
pubmed-meshheading:6265964-Norepinephrine,
pubmed-meshheading:6265964-Rats,
pubmed-meshheading:6265964-Receptors, Dopamine,
pubmed-meshheading:6265964-Receptors, Neurotransmitter,
pubmed-meshheading:6265964-Serotonin,
pubmed-meshheading:6265964-Tranylcypromine,
pubmed-meshheading:6265964-gamma-Aminobutyric Acid
|
pubmed:year |
1981
|
pubmed:articleTitle |
Studies on possible mechanisms of action of electroconvulsive therapy; effects of repeated electrically induced seizures on rat brain receptors for monoamines and other neurotransmitters.
|
pubmed:publicationType |
Journal Article
|