| pubmed-article:6264449 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C0032136 | lld:lifeskim |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C0040077 | lld:lifeskim |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C0814810 | lld:lifeskim |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:6264449 | lifeskim:mentions | umls-concept:C1150506 | lld:lifeskim |
| pubmed-article:6264449 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6264449 | pubmed:dateCreated | 1981-8-20 | lld:pubmed |
| pubmed-article:6264449 | pubmed:abstractText | A hybrid plasmid (pAGO) that contains the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) gene in the form of a 2-kilobase-pair (kbp) Pvu II fragment inserted at the Pvu II site of plasmid pBR322 was used to transform TK- Escherichia coli K-12 strain KY895. pAGO-transformed KY895 cells exhibited partially restored ability to incorporate [3H]dThd into DNA and an HSv-1-specific TK activity. Bacteria cured of plasmid pAGO (or transformed by plasmid pBR322) did not show enhanced incorporation of [3H]dThd into DNA or HSV-1 TK activity. Plasmid pMH1A was derived from pAGO by deletion of 2067 bp of DNA sequence from pBR322 and 105 bp from the HSV-1 TK gene. E. coli K-12 strain KY895 cells transformed by pMH1A did not show enhanced incorporation of [3H]dThd into bacterial DNA, although pMH1A DNA isolated from transformed KY895 cells, like pAGO DNA, did transform TK- mouse fibroblast [LM(TK-)] cells to the TK+ phenotype. The expression of HSV-1 TK activity by E. coli K-12 suggests that intervening sequences may be absent from the coding region of HSV-1 tk or that the coding region of the gene possesses short intervening sequences which do not disrupt the translational reading frame. | lld:pubmed |
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| pubmed-article:6264449 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6264449 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6264449 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6264449 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6264449 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:6264449 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6264449 | pubmed:author | pubmed-author:OtsukaHH | lld:pubmed |
| pubmed-article:6264449 | pubmed:author | pubmed-author:KitSS | lld:pubmed |
| pubmed-article:6264449 | pubmed:author | pubmed-author:HazenMM | lld:pubmed |
| pubmed-article:6264449 | pubmed:author | pubmed-author:QaviHH | lld:pubmed |
| pubmed-article:6264449 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6264449 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:6264449 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6264449 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6264449 | pubmed:pagination | 582-6 | lld:pubmed |
| pubmed-article:6264449 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6264449 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6264449 | pubmed:articleTitle | Herpes simplex virus thymidine kinase activity of thymidine kinase-deficient Escherichia coli K-12 mutant transformed by hybrid plasmids. | lld:pubmed |
| pubmed-article:6264449 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6264449 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6264449 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6264449 | lld:pubmed |
