Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1977-1-29
|
| pubmed:abstractText |
The benzimidazole derivative Hoechst 33258 was added at various concentrations to human leukocyte cultures. After 16 or 24 h of treatment, with concentrations equal to or greater than 100 mug/ml of Hoechst 33258, a number of chromosomes showed regions in which the chromatin was undercontracted. The centromeric regions of chromosome 1 and, more rarely, of chromosomes 3 and 9 appeared to be decondensed. Short decondensed regions were also present on the long arms of chromosomes 1 and 2. The possible nature of these regions is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0301-0171
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
114-21
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:62642-Benzimidazoles,
pubmed-meshheading:62642-Bisbenzimidazole,
pubmed-meshheading:62642-Cell Division,
pubmed-meshheading:62642-Chromosomes,
pubmed-meshheading:62642-Dose-Response Relationship, Drug,
pubmed-meshheading:62642-Humans,
pubmed-meshheading:62642-Leukocytes,
pubmed-meshheading:62642-Male,
pubmed-meshheading:62642-Mitosis
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Effects of Hoechst 33258 on human leukocytes in vitro.
|
| pubmed:publicationType |
Journal Article
|