| pubmed-article:6263892 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6263892 | lifeskim:mentions | umls-concept:C0012920 | lld:lifeskim |
| pubmed-article:6263892 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:6263892 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:6263892 | lifeskim:mentions | umls-concept:C0982459 | lld:lifeskim |
| pubmed-article:6263892 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:6263892 | pubmed:dateCreated | 1981-8-10 | lld:pubmed |
| pubmed-article:6263892 | pubmed:abstractText | Wheat germ contains an enzyme capable of removing supercoils from circular DNA. We have purified this enzyme using Polymin P fractionation, ammonium sulfate precipitation, and chromatography on Bio-Rex 70 and phenyl-Sepharose. Renaturation after electrophoresis on sodium dodecyl sulfate-polyacrylamide gels shows that topoisomerase activity is associated with a polypeptide with a Mr = about 111,000. The enzyme is similar to other eukaryotic type I DNA topoisomerases (nicking-closing enzymes) by the following criteria: it is capable of increasing or decreasing the topological linking number of covalently closed DNA substrate; it is capable of restoring an equilibrium distribution of linking numbers to DNA substrate with a single unique linking number; and it does not require magnesium ion or ATP for activity. | lld:pubmed |
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| pubmed-article:6263892 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6263892 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6263892 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6263892 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6263892 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6263892 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:6263892 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:6263892 | pubmed:author | pubmed-author:BurgessR RRR | lld:pubmed |
| pubmed-article:6263892 | pubmed:author | pubmed-author:HagerD ADA | lld:pubmed |
| pubmed-article:6263892 | pubmed:author | pubmed-author:DynanW SWS | lld:pubmed |
| pubmed-article:6263892 | pubmed:author | pubmed-author:JendrisakJ... | lld:pubmed |
| pubmed-article:6263892 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6263892 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:6263892 | pubmed:volume | 256 | lld:pubmed |
| pubmed-article:6263892 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6263892 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6263892 | pubmed:pagination | 5860-5 | lld:pubmed |
| pubmed-article:6263892 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6263892 | pubmed:meshHeading | pubmed-meshheading:6263892-... | lld:pubmed |
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| pubmed-article:6263892 | pubmed:meshHeading | pubmed-meshheading:6263892-... | lld:pubmed |
| pubmed-article:6263892 | pubmed:meshHeading | pubmed-meshheading:6263892-... | lld:pubmed |
| pubmed-article:6263892 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6263892 | pubmed:articleTitle | Purification and characterization of wheat germ DNA topoisomerase I (nicking-closing enzyme). | lld:pubmed |
| pubmed-article:6263892 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6263892 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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