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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1981-8-10
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pubmed:abstractText |
The effect of disopyramide on neuromuscular transmission has been studied using the rat isolated phrenic nerve-diaphragm preparation. The response of the muscle to indirect nerve stimulation was decreased in the presence of disopyramide 5.6 x 10(-6) mol litre-1 (P less than 0.05), total blockade occurring at 5.6 x 10(-4) mol litre-1. Marked augmentation of the response to direct muscle stimulation was recorded in the presence of disopyramide 1.8 x 10(-4)-5.6 x 10(-4) mol litre-1. Disopyramide 5.6 x 10(-6) mol litre-1 caused a leftward shift of the log concentration response for tubocurarine and decreased the antagonist effect of neostigmine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
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pubmed:issn |
0007-0912
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
495-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6263303-Animals,
pubmed-meshheading:6263303-Disopyramide,
pubmed-meshheading:6263303-Dose-Response Relationship, Drug,
pubmed-meshheading:6263303-Drug Synergism,
pubmed-meshheading:6263303-Neostigmine,
pubmed-meshheading:6263303-Neuromuscular Junction,
pubmed-meshheading:6263303-Pyridines,
pubmed-meshheading:6263303-Rats,
pubmed-meshheading:6263303-Synaptic Transmission,
pubmed-meshheading:6263303-Tubocurarine
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pubmed:year |
1981
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pubmed:articleTitle |
Disopyramide and neuromuscular transmission.
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pubmed:publicationType |
Journal Article,
In Vitro
|