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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1977-1-25
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pubmed:abstractText |
Lymphocyte-enriched mononuclear cell fractions were obtained from the peripheral blood of four healthy young adults. Living B cells with membrane immunoglobulin (Ig) were studied by immunofluorescence to reveal exposed J-chain determinants or surface affinity for the secretory component (SC). Alcohol-fixed cell smears were similarly studied with and without prior denaturation in acid urea. It was concluded that J chain-containing polymeric Ig of endogenous origin is generally not present on the surface of circulating B cells. If occasional cells bear IgM or IgA polymers rather than monomers, their SC-binding site must be concealed to a degree that it is not functional. Affinity for SC is therefore unlikely to be involved in a selective homing of IgM- and IgA-immunocyte precursors from peripheral blood to glandular regions.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-1080167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-1089743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-1090663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4104295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4125613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4137572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4137689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4138813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4139226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4142108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4208585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4213975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4214117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4214707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4218361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4542737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4595982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4604796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4816299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4882659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4934147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-4997586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-769144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-803523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-804004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-804005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-804239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-809834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-810882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/62630-814614
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
50-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:62630-Adult,
pubmed-meshheading:62630-Antigen-Antibody Complex,
pubmed-meshheading:62630-B-Lymphocytes,
pubmed-meshheading:62630-Cell Membrane,
pubmed-meshheading:62630-Epitopes,
pubmed-meshheading:62630-Humans,
pubmed-meshheading:62630-Immunoglobulin A,
pubmed-meshheading:62630-Immunoglobulin Fragments,
pubmed-meshheading:62630-Immunoglobulin J-Chains,
pubmed-meshheading:62630-Immunoglobulin M,
pubmed-meshheading:62630-Receptors, Antigen, B-Cell,
pubmed-meshheading:62630-Secretory Component
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pubmed:year |
1976
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pubmed:articleTitle |
Studies on J chain and binding site for secretory component in circulating human B cells.
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pubmed:publicationType |
Journal Article
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