|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1981-7-20
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|
pubmed:abstractText |
The mechanism of clonidine-induced hyperphagia and weight gain in monkeys was studied in 11 Stumptail macaques. Clonidine induced a significant increase in food intake over baseline levels and a significant weight gain after the 3-day treatment period. Both changes induced by clonidine were antagonized by the alpha 2-noradrenergic antagonist yohimbine, but not by prazosin, an alpha 1-noradrenergic antagonist. These results suggest that clonidine-induced hyperphagia and weight gain in monkeys are mediated through alpha 2-noradrenergic receptors.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0033-3158
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
73
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
99-100
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6262851-Animals,
pubmed-meshheading:6262851-Clonidine,
pubmed-meshheading:6262851-Drug Interactions,
pubmed-meshheading:6262851-Eating Disorders,
pubmed-meshheading:6262851-Humans,
pubmed-meshheading:6262851-Hyperphagia,
pubmed-meshheading:6262851-Macaca,
pubmed-meshheading:6262851-Norepinephrine,
pubmed-meshheading:6262851-Receptors, Adrenergic,
pubmed-meshheading:6262851-Receptors, Adrenergic, alpha,
pubmed-meshheading:6262851-Sympathomimetics
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|
pubmed:year |
1981
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|
pubmed:articleTitle |
Clonidine-induced hyperphagia in monkeys: evidence for alpha 2-noradrenergic receptor mediation.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
