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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1981-7-23
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pubmed:abstractText |
Antibodies raised in goats against the rat hepatic receptor for desialylated glycoproteins were perfused through a rat liver and were specifically retained by the liver. These antireceptor antibodies also bound specifically to hepatocyte plasma membranes oriented with their cytoplasmic surface outward on polylysine-derivatized beads. These two phenomena were judged to be properties of distinct subpopulations of the antibody preparation because: (i) maximal adsorption of antibodies with membranes on polylysine beads did not affect subsequent retention by the perfused liver, and (ii) whereas perfusion resulted in a depletion of antibodies capable of blocking ligand binding, adsorption by the everted membrane preparation led to a relative enrichment of blocking antibodies. These results are interpreted as indicative of distinct antigenic determinants of the receptor being present on the two faces of the membrane and demonstrate a transbilayer disposition of the asialoglycoprotein receptor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-1260065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-13713200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-189940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-191195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-201867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-21192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-221835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-402030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-4263713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-4327329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-4368906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-4609051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-4611171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-5472375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-5545089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-620024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-6244303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-6771265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-697750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-70230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-7370245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-7407914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-7410409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-762112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-786159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-826530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-831278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-88659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6262814-893426
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1557-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6262814-Animals,
pubmed-meshheading:6262814-Antibodies,
pubmed-meshheading:6262814-Antigen-Antibody Complex,
pubmed-meshheading:6262814-Asialoglycoprotein Receptor,
pubmed-meshheading:6262814-Cell Membrane,
pubmed-meshheading:6262814-Glycoproteins,
pubmed-meshheading:6262814-Immunoassay,
pubmed-meshheading:6262814-Kinetics,
pubmed-meshheading:6262814-Liver,
pubmed-meshheading:6262814-Male,
pubmed-meshheading:6262814-Rats,
pubmed-meshheading:6262814-Receptors, Cell Surface
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pubmed:year |
1981
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pubmed:articleTitle |
Immunological evidence for the transmembrane nature of the rat liver receptor for asialoglycoproteins.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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